CBD and THC

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Cannabis

• Types of Cannabis
  • Cannabis Sativa -- promotes creativity, daytime use
  • Cannabis Indica -- couch-lock, good for pain, sleep, evening use
  • Hybrids -- mixing Sativa and Indica genetics

• Half-Life of Certain Chemicals
  • Nicotine: 1-2 hours
  • Caffeine: 5-6 hours
  • Theobromine (chocolate): 7-10 hours
  • THC: 12-24 hours (can build up in the fat tissue)
  • CBD: 18-32 hours (can build up in the fat tissue)
    • The half-life of CBD can range from 1 hour to 5 days. CBD sprays
      and drops have a half-life of 1.4-10.9 hours. Chronic oral consumption
      of CBD producs can increase its half-life to 2-5 days. Genrally, the
      effects of CBD can last from 2-6 hours.

  • The bioavailability of ingested THC is 4%-12%, and the
    bioabailability of ingested CBD is 6%. If we use the lower
    range for THC, a 1:1 ratio would be 7.5mg THC to 5.0mg CBD,
    which is NOT the classic definition of a 1:1 ratio.

  • Ignoring the THCA in cannabis, the ratio of THC:CBD is 12:1.
    If we include the THCA in our THC concentraion, then the ratio of
    THC:CBD is 400:1.

  • All this data suggests that people MAY be taking TOO MUCH
    CBD in relationship to the amount of THC they are taking for pain.

  • How Long Does CBD Stay in Your System @ healthline.com (01/26)

• Chemical Composition of Cannabis
  • Chemicals in Commercial Cannabis

    Tetrahydrocannabinolic acid	THCA	148.833 +/- 19.364
    Delta-9-tetrahydrocannabinol	THC	4.792 +/- 1.908
    Cannabicyclol	CBL	0.778 +/- 0.581
    Cannabigerol	CBG	0.738 +/- 0.456
    Cannabichromene	CBC	0.605 +/- 0.402
    Cannabinol	CBN	0.412 +/- 0.226
    Cannabidiol	CBD	0.385 +/- 0.246

  • THCA is non-psychoactive in its raw form, while THC is the psychoactive
    compound that produces a "high". THCA, the natural precursor to THC found in
    raw cannabis, converts into THC when exposed to heat (smoking, baking/cooking,
    prolonged exposure to light or air over time).

• Chemistry, Metabolism, and Toxicology of Cannabis @ nih.gov (12/25)

• Human Cannabinoid Pharmacokinetics @ nih.gov (12/25)
  • Smoking
    • Bioavailability following the smoking route was reported as 2−56%
    • THC, detected in plasma immediately after the first cigarette puff, was
      accompanied by the onset of cannabinoid effects
    • The average concentrations in more than 30,000 cannabis preparations
      (confiscated in the U.S. between 1980 and 1997) were 3.1% THC
      and only 0.3% CBD
  • Oral
    • Absorption is slower when cannabinoids are ingested, with lower,
      more-delayed peak THC concentrations
    • Oral THC bioavailability was reported to be 10−20% in a capsule
      containing oil
    • Oral bioavailability was estimated to be 6% after ingestion of a
      chocolate cookie (oral bioavailability of 4−20%)
  • Transcutaneous
    • Permeabilities of CBD and CBN were found to be 10-fold higher
      than for Delta-8 THC
    • Transdermal delivery also bypasses first-pass metabolism of
      cannabinoids

• Mechanisms of Action and Pharmacokinetics of Cannabis @ noh.gov (01/26)
  • The bioavailability of inhaled THC is 10% to 35%
  • The bioavailability of ingested THC is only 4% to 12%
  • The plasma half-life of THC is 1-3 days in occasional users,
    and 5-13 days in chronic users
  • The bioavailability of CBD via inhalation is 11% to 45%, whereas
    that of oral CBD is 6%
  • The plasma half-life of CBD is 18 to 32 hours

• Cannabis and the Liver
  • Information
    • "Cannabis hangover" feeling can last 24-72 hours
    • Your liver converts THC into 11-hydroxy-THC, which is more potent
      and long-lasting than regular THC, creating extended effects
    • Edibles go through the liver first, potentially increasing intensity,
      while smoking delivers THC quickly to the bloodstream

  • Cannabis and the Liver @ nih.gov (12/25)

• Cannibus is more than simply Delta-9 @ nih.gov (12/25)

• CB1 vs CB2 Receptors @ hometownhero.com (01/26)

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CBD (Cannabidiol)

• CBD
  • Epidiolex is prescription-level CBD used to treat seizures associated with
    specific, rare forms of epilepsy
  • The 2018 Farm Bill removed CBD from the definition of marijuana in the
    Controlled Substances Act
  • CBD is non-psychoactive
  • It interacts with CB1 and CB2 receptors in the ECS
  • CBD is known for its potential therapeutic benefits, including anti-inflammatory,
    anxiolytic, and antipsychotic properties
  • It is commonly used to alleviate anxiety, manage pain, and reduce seizures
    in conditions like epilepsy
  • CBD interacts with serotonin receptors (like 5-HT1A), similar to how some
    antidepressants work, influencing mood and anxiety
  • CBD may promote new neuron growth and synaptic plasticity, which are crucial
    for mood regulation
  • Taking CBD with a high-fat meal can cause much higher levels of CBD in your blood
  • Benefits of CBD and THC Together @ beeZbeecbd.com (01/26)

• CBD Dosage
  • Permeability
    • CBD (cannabidiol) possesses moderate-to-high skin permeability for topical use
    • Pure CBD has poor oral bioavailability due to low water solubility and low
      permeability in the gastrointestinal tract. Formulations using nanoparticles,
      phospholipids, or exosomes can significantly increase this absorption
    • CBD can pass through the BBB, with free CBD showing permeability comparable
      to progesterone

  • How Much CDB Oil Should I Take for Pain? (12/25)
    • A general guideline to start with is approximately 0.2 mg of CBD per pound
      of body weight.
    • 150 lbs * 0.2 mg/lb = 30mg CBD
    • Try starting with 5-10 mg of CBD per day and working your way up slowly each day
    • CBD reaches toxic levels at 20,000 mg
    • Doses up to 1,500 mg daily are well-tolerated

  • The Entourage Effect
    • CBD+THC in a 1:1 ratio is often called the "golden ratio"
    • The 1:1 ratio aims for a functional calm, providing mild euphoria with
      therapeutic relief
    • A 1:1 ratio with a low dose (e.g., 5mg THC and 5mg CBD per gummy) is often
      recommended as an appropriate starting point for those new to cannabis edibles

  • Cannabis Treatment for Pain @ goodrx.com (01/26)
    • Experts recommend starting with 10 mg per day of a high-CBD formulation
      and slowly increasing the dose up to 40 mg daily.
    • Your provider may then add 2.5 mg of THC daily and slowly increase up to a
      maximum of 40 mg daily if needed.

  • Analgesic Effects of Oral CBD @ nih.gov (01/26)
    • Few studies have examined CBD's analgesic effects when administered without
      other compounds
    • CBD failed to consistently affect pain threshold and tolerance in the CPT
      relative to placebo. All doses of CBD increased ratings of painfulness
      compared to placebo.

  • Products Fail to Reduce Pain @ koin.com (01/26)
    • Products mainly or only containing CBD – which offers no psychoactive
      properties – show almost no improvement in pain management

  • CBD - An Effective Analgesic for Toothache?@ nih.gov (01/26)
    • Epidiolex is an FDA-approved CBD oral solution (100mg/ml) derived from
      the cannabis plant. The maximum recommended daily dose of Epidiolex is 20 mg/kg.

  • 8 Reasons CBD Might Not Be Working for Your Arthritis @ creakyjoints.org (01/26)

• Nano-emulsification
  • General Information
    • Nano-emulsification effectively "tricks" the body into absorbing the THC more
      efficiently, primarily through the mucous membranes in the mouth and stomach lining,
      partially bypassing the slow digestive process.
    • Effects typically begin within 15 to 30 minutes, compared to the 60-120 minutes
      for traditional edibles
    • A greater percentage of the consumed THC is absorbed into the bloodstream, meaning
      smaller doses can produce similar effects to larger traditional doses.
    • The even dispersion of particles ensures consistent potency in each serving
    • The effects typically last 2-4 hours, rather than 6-8 hours for edibles
    • Look for labels that mention "nano", "water-soluble", or "fast-acting THC"

  • What is Nano Delta-9? @ thewholesale.com (01/26)

  • Nano-emulsion @ sunmedgrowers.com (12/25)
    • Ingredients include
      • Cannabinoids: THC and/or CBD
      • Surfactants: lecithin and polysorbate
      • Cosurfactants: ethanol and glycerin
      • Aqueous Phase: water or a water-based solution

    • Applications
      • Cannabis Beverages
      • Edibles
      • Topicals
      • Tinctures and Sublingual

• Preparation Differences
  • Full-spectrum products have less than 0.3% THC (most effective)
  • Broad-spectrum products have 0.0% THC
  • Isolate only contains CBD, no other compound (less effective)
    • A study from 2018 also has shown that full-spectrum CBD was more effective
      for pain relief when compared to isolate CBD

      

• Benefits
  

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CBG (Cannabigerol)

• Information
  • CBG is a non-psychoactive cannabinoid
  • CBG shows promise for its potential anti-inflammatory and neuroprotective effects
  • Clinical trials have shown that 20mg of CBG can significantly reduce anxiety
    and stress within 20 to 60 minutes
  • CBG increases the body's natural production of anandamide, which regulates
    reward, pleasure, and mood, leading to natural elevation
  • CBG is commonly described as the "clarity cannabinoid", promoting alertness
    and mental focus
  • It interacts with 5-HT1A receptors that regulate serotonin levels
  • CBG can cause dry mouth followed by sleepiness and increased appetite
  • CBD half life generally ranges from 18-32 hours for a single dose
  • Oral CBD (edibles, oils) have a half life of 1-2 days for a single dose;
    that can extend to 2-5 days with chronic use

• CBD vs CBG
  • CBG vs CBD @ drgreenrelief.com (12/25)

  • CBG has stronger anti-inflammatory and analgesic effects on nerve tissue
    than CBD. It specifically targets receptors involved in pain and inflammation more
    directly.
  • CBD is effective for general pain and inflammation, with some evidence of
    protection against nerve injury. It helps reduce pain but may be less potent than
    CBG for specific nerve pain applications.
  • CBD mostly works by supporting your body's own cannabinoids
  • CBG works differently, as it binds directly to both CB1 and CB2 receptors
  • CBD is used for general soreness, anxiety, stress
  • CBG is used for chronic neuropathy, nerve damage
  • While CBD is known for calming, CBG is reported to be more uplifting,
    energizing, and mentally activating
  • CBD and CBG are often found in a 2:1 or 1:2 ratio

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CBN (Cannabinol) and CBC (Cannabichromene)

• CBN
  • CBN is a degradation product of THC, formed when THC oxidizes
  • It is mildly psychoactive but less potent than THC
  • Some studies suggest CBN may have sedative effects and could be useful
    for sleep disorders

• CBC
  • CBC is another non-psychoactive cannabinoid
  • It may have anti-inflammatory and analgesic properties

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THC (Delta-9 & Delta-8)

• Information
  • Is Delta 9 the Same as THC? @ musclemx.com (01/26)

  • When THC reaches the brain, it binds to CB1 receptors located in areas
    responsible for memory, pleasure, coordination, and time perception. Additionally,
    THC affects the hippocampus, impacting short-term memory and learning capabilities.
    THC also stimulates appetite by affecting the hypothalamus, causing the munchies.

• General Dosage Guidelines for Edibles
  • 1-2.5mg -- mild symptom relief, no intoxication (microdose)
  • 2.5-5mg -- stronger relief, mild euphoria, recreational use, better sleep
  • 10-15mg -- effective relief for pain, altered perception, high-tolerance users
  • 20-50mg -- significant impairment (couch lock)
  • 50+mg -- very high dose (special medical needs)

  • Start with 2.5 mg if you are new to THC, especially with edibles

• Duration by Consumption Method

  Method	Onset Time	Duration of High
  Edibles	0.5-2 hrs	4-8 hours
  Tinctures	20-30mins	2-4 hours
  Smoking	minutes	1-3 hours

• How to eat gummies
  • On an empty stomach
    • Quicker onset of effects (potentially within 30-45 minutes)
    • Effects may feel stronger
    • Effects may not last as long
    • Some people may experience mild side effects such as nausea, dizziness,
      or an upset stomach
    • If the gummies contain oil, then an empty stomach works well
  • On a full stomach (especially with fatty foods)
    • Enhanced absorption and increased bioavailability
    • Longer-lasting effects, ideal for all-day relief or overnight use
    • Reduced risk of stomach discomfort or nausea
    • Slower onset of effects (can take 1-2 hours or more)

• Delta forms of THC

  • What is Nano Delta-9? @ thewholesale.com (01/26)

  • Overview
    • Delta-8 THC and Delta-9 THC are isomers with identical chemical formulas,
      but differ structurally in the location of a single double bond in their carbon chain
    • This minor difference in the position of the double bond significantly changes
      how each compound interacts with the body's endocannabinoid system (ECS),
      particularly the CB1 receptors in the brain and nervous system
    • Delta-9 THC binds more strongly and efficiently to the CB1 receptors
    • Delta-8 THC has a weaker binding affinity, resulting in a milder, less intense,
      and often more clear-headed experience compared to Delta-9
    • Delta-8 THC is a more stable compound than Delta-9, which makes it a better
      candidate for certain therapeutics and gives it a longer shelf life.
    • Delta-9 is extracted directly from cannabis plant material
    • Delta-8 is typically synthesized from hemp-derived CBD through chemical
      conversion

  • Delta-9 THC
    • Delta-9 THC is the primary psychoactive compound -- intense effects
    • Primary compound in cannabis
    • Intense "high" with stronger mental effects, can cause anxiety/paranoia
      in some users

  • Delta-8 THC
    • Delta-8 THC is the less potent isomer
    • Milder, about half to two-thirds as potent as delta-9
    • Typically derived from hemp
    • Gentler high, often described as a "clear-headed" or more functional
      "body high" with less anxiety
    • Most commercial products are semi-synthetic, converted from hemp-derived CBD
    • Delta-8 THC is a popular choice for those who want the therapeutic benefits
      of THC without the intense, potentially overwhelming psychoactive effects

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Interactions

• General Information
  • CBD competes with liver enzymes (cytochrome P450) that metabolize many drugs,
    including Tylenol, which can alter medication levels in your blood

  • You should not take CBD with drugs metabolized by the CYP3A4 enzyme, including
    blood thinners (like warfarin), certain seizure meds (clobazam, valproate),
    heart drugs (amiodarone, some statins), antidepressants, opioids, and thyroid meds,
    as it can dangerously increase their levels, similar to grapefruit juice interactions

  • If a drug label warns against consuming it with grapefruit juice, you should also
    avoid taking it with CBD, as they interact with the same liver enzymes

  • CBD can cause dry mouth, diarrhea, reduced appetite, drowsiness and fatigue

• Blood Thinners
  • CBD can have a clinically significant and potentially dangerous interaction with
    blood thinners, increasing the risk of excessive bleeding
  • CBD slows down the liver's ability to process the blood thinner, leading to
    higher-than-intended levels of the medication in the bloodstream
  • Warfarin has a high risk of interaction
  • Eliquis and Xaralto have a potential risk of interaction
  • Pradaxa, Lixiana, and Heparin have a lower risk of interaction
  • An Interaction Between Warfarin and Cannabidiol @ nih.gov (01/26)
    • Patient was taking warfarin 7.5 mg daily
    • He was placed on the starting dose of CBD at 5 mg/kg/day, divided
      twice daily (equivalent to 340mg daily for a 150-pound person)
    • Per study protocol, the CBD dose was increased in 5 mg/kg/day
      increments every two weeks

• Chocolate
  • Mixing chocolate and THC creates a potent and popular edible combination due to a
    unique biochemical synergy that can enhance and prolong the effects of the cannabis
  • Chocolate contains anandamide, an endocannabinoid produced naturally by the brain
    that regulates mood and pleasure. THC mimics anandamide, and the other compounds in
    chocolate help slow the breakdown of anandamide, effectively boosting the body's
    natural feel-good chemistry.
  • Compounds in chocolate can improve the bioavailability of THC, meaning more of
    the compound makes it into your system for absorption rather than passing through
    unmetabolized

• Coffee
  • Caffeine is a stimulant that works by blocking adenosine receptors in the brain
  • Caffeine can amplify the effects of THC, sometimes leading to a more intense
    experience
  • If you're sensitive to cannabis, combining it with caffeine might result in an
    unpleasantly strong high
  • Some research suggests caffeine may potentiate the short-term memory deficits
    caused by THC
  • Mixing coffee and THC can cause increased heart rate and elevated blood pressure
  • CBD interacts with the body's endocannabinoid system, which helps regulate
    balance (homeostasis), mood, and stress response
  • CBD may slow down how the liver metabolizes caffeine

• Diabetes
  • Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance @ nih.gov (12/25)

• Metformin
  • Combining CBD and metformin can cause an increased risk of hypoglycemia,
    and heightened side effects like diarrhea
  • Both CBD and metformin can lower blood glucose levels, although they work
    through different mechanisms
  • Metformin makes cells more responsive to insulin and increases lipid metabolism.
    CBD acts on the body's endocannabinoid system (ECS) and may be responsible for
    the increased amount of insulin in the body.
  • Metformin is not metabolized by liver enzymes, but it can affect the activity
    of the CYP3A4 enzyme. CBD is an inhibitor of this and other CYP450 enzymes.
    Taking them together could slow the metabolism and elimination of other drugs
    processed by these enzymes
  • So far, no cases of adverse reactions have been reported when the two medicines
    are used together
  • Start with low doses of CBD, and separate the doses of both medications by
    approximately two hours to minimize potential side effects and interactions

• Tryptophan
  • CBD and L-tryptophan (along with B6) are combined in sleep gummies to help
    users fall asleep faster and stay asleep longer
  • CBD may increase the availability of circulating tryptophan by suppressing
    its degradation (via indoleamine-2,3-dioxygenase), thereby supporting
    serotonin biosynthesis

• Tylenol
  • Took CBD+CBG with Tylenol: nerves burned all over the body for 4 hours
  • CBD prevents the liver from decomposing Tylenol

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Brain

• Migraine
  • Efficacy and Safety of Medical Marijuiana in Migraine Headache @ nih.gov (01/26)
    • Medical marijuana treatment for migraine is becoming more common
    • It decreases the frequency of migraine by having an impact on the
      endocannabinoid system
    • Medical marijuana has a significant clinical response by reducing the length
      and frequency of migraines.
    • No severe adverse effects were noted
    • THC
      • THC acts as an agonist on cannabinoid receptor one (CB1R)
      • THC uses endogenous G-protein-coupled receptor (GPCR)
        signaling to repair migraine-related pathways
      • THC can also act as a dopamine antagonist when given in
        larger doses
      • Cannabis also shares a similar mechanism of action with
        headache and migraine drugs in that they both lower plasma
        glutamate levels
      • Magnesium levels are frequently low during headaches and
        migraines
    • CBD
      • CBD's effects on the body are more complex
      • CBD's metabotropic effects include balancing excitatory
        brain signaling
      • The ionotropic effects of CBD include a decrease in sodium
        current through the stabilization of lipid membranes connected
        to voltage-gated sodium channels (Na V)
      • CBD's antagonistic effects on GPR55 cause a rise in inhibitory
        neural transmission, which may help migraine and seizure patients
        by calming their brains
    • The endocannabinoid system (ECS) is a broad signaling network that
      is found in almost all cell types and is essential for preserving bodily
      homeostasis. The central and peripheral nervous systems' stress-responsive
      regions have an active ECS that works to lessen pain and prevent
      neurodegeneration and inflammatory damage. There is evidence that
      endocannabinoids cause plastic changes in numerous brain regions that
      control pain perception in their short-term effects.

    • 2018 Study
      • Patients in the study trial received 19% THC, or 19% THC with 9% CBD
      • A total of 200 mg was found to be an effective amount for reducing
        migraine pain by 55%

    • Another Study
      • In a different study, patients with chronic migraines received either
        25 mg of amitriptyline or 200 mg of THC and CBD daily for three months as a
        preventative measure; 200 mg of THC and CBD was also necessary for an acute
        attack. The results of the study showed that 200 mg of THC with CBD was
        superior to amitriptyline use.

    • 2020 Study
      • Mechtler et al. in 2020 studied the dosing for cannabis in migraine
        patients, and concluded that dosing for medical cannabis is an
        individualized procedure that is influenced by the underlying
        endocannabinoid tone.

  • Short- and Long-Term Effects of Cannabis on Headache and Migraine @ nih.gov (01/26)
    • Headaches were reduced by 47.3% and migraines by 49.6%
    • A total of 88.1% of patients reported a reduction in migraine severity
      with inhaled cannabis
    • The average THC concentration was 14.9%, ranging from 0 to 77%, and the
      average CBD concentration was 2.58%, ranging from 0 to 50.7%
    • Neither the THC nor CBD concentration had any influence on reducing severity
    • Regardless of dosage, cannabis preparation, flower, or concentration,
      severity was also decreased

  • Experience of Migraine Among Cannabis Users @ nih.gov (01/26)
    • Even after controlling for migraine severity, cannabis users reported
      considerably higher migraine relief than users of non-cannabis products

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Diabetes

• CBD
  • CBD Lowers Incidence of Diabetes in Non-obese Diabetic Mice @ nih.gov (01/26)
    • CBD treatment significantly reduces the incidence of diabetes in NOD mice
      from an incidence of 86% in non-treated control mice to an incidence of
      30% in CBD-treated mice.

  • CBD Use in Type 2 Diabetes: A Case Report @ nih.gov (01/26)

  • Unlocking the Antidiabetic Potential of CBD: In Vivo Preclinical Studies @ nih.gov (01/26)
    • In diabetic rats, metformin and 25 mg/kg CBD lowered blood glucose,
      but only CBD increased insulin
    • This study provides strong evidence of CBD's antidiabetic potential,
      especially at 50 mg/kg, particularly through its modulation of glucose
      metabolism and tendency to regulate insulin levels.

  • Pseudo-CBD (H4CBD) Improves Glucose Response in Rats @ nih.gov (01/26)

  • The Pharmacology and Therapeutic Role of CBD in Diabetes @ nih.gov (01/26)

• THC
  • Efficacy and Safety of CBD and THCV on Patients with Type 2 Diabetes @ diabetesjournals.org (01/26)
    • CBD and Delta9-tetrahydrocannabivarin (THCV) are nonpsychoactive phytocannabinoids
      affecting lipid and glucose metabolism in animal models
    • 62 subjects with noninsulin-treated type 2 diabetes were randomized to five treatment arms:
      CBD (100 mg twice daily), THCV (5 mg twice daily), 1:1 ratio of CBD and THCV
      (5 mg/5 mg, twice daily), 20:1 ratio of CBD and THCV (100 mg/5 mg, twice daily), or
      matched placebo for 13 weeks
    • Compared with placebo, THCV significantly decreased fasting plasma glucose
    • THCV could represent a new therapeutic agent in glycemic control in subjects
      with type 2 diabetes

  • Cannabis and Diabetes @ diabetes.co.uk (01/26)
    • A 2016 study found that THCV and CBD decreased blood glucose levels and
      increased insulin production in people with type 2 diabetes, indicating a
      "new therapeutic agent for glycemic control"
    • GW Pharmaceuticals is currently developing a cannabis spray called Sativex,
      (CBD and THCV compounds) to help with blood sugar regulation in people with
      type 2 diabetes

  • Cannabis and Diabetes @ beyondtype1.org (01/26)
    • Inhaled marijuana tends to have a more immediate impact on blood sugar levels—
      some people report that their blood sugar levels start to drop almost immediately
      after consumption. Others report that their blood sugar spikes.
    • Smoking always makes my blood sugar go low naturally

  • Cannabis, THC and Blood Sugar @ ccsmed.com (01/26)
    • THC may lower blood sugar
    • THC can increase an individual's heart rate as well as blood pressure,
    • THC can potentially reducing nerve pain in individuals suffering from neuropathy

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Eyes & Ears

• Effects on the Eyes
  • Delta-9 THC
    • Marijuana lowers IOP by up to 45%; however, it peaks at 30 minutes and
      decreases after 60 minutes, generally lasting only three to four hours

    • Marijuana can lead to pupil dilation

    • THC lowers blood pressure, causing blood vessels in the eyes to expand
      (vasodilation)

    • When THC and other cannabinoids interact with the brain's endocannabinoid system,
      they can alter neurotransmitter release and affect various neural circuits. Specifically,
      these compounds can influence areas of the brain that process visual information,
      such as the occipital lobe. This can lead to alterations in visual perception, including
      heightened colors, patterns, and in some cases, the perception of flashing lights or
      visual hallucinations.

    • Flashing lights in vision can be caused by migraine aura. A migraine aura is a
      wave of electrical activity spreading across the brain's cortex . Smoking
      substances like cannabis may sometimes trigger or worsen visual symptoms.

    • Adverse Ocular Impact and Potential of Cannabis @ dovepress.com (12/25)
      • Animal studies demonstrate anti-inflammatory and analgesic properties,
        corneal regenerative effects, and retinal neuroprotective effects of
        cannabinoids
      • Oral THC improves night vision, probably affecting the retina by
        stimulating the visual rods
      • The neuroprotective and antioxidant effects of THC and CBD may have
        additional applications in other eye diseases such as senile macular
        degeneration, or in the vascular retinopathy of glaucoma, where similar
        claims for therapeutic clinical cannabis are abundant

  • Delta-8 THC
    • Delta-8 may act similar to Delta-9 in the eyes
    • Delta-8 reduces corneal pain and inflammation

  • CBD
    • CBD isn't the cannabinoid responsible for IOP reduction
    • THC administration significantly lowered IOP transiently, but CBD —
      in large doses — had the opposite effect, temporarily increasing IOP
    • CBD can raise intraocular pressure by as much as 18% for at least four
      hours after use

• Effects on the Ears
  • THC
    • THC impacts the endocannabinoid system (ECS) in the inner ear, which
      plays a role in balance and hearing
    • THC can also act as a "psycho-acoustic enhancer", increasing sensitivity
      to sound

  • CBD
    • CBD may have neuroprotective or anti-inflammatory properties
      for the cochlea

  • Tinnitus
    • Cannabinoids may exacerbate tinnitus
    • Tinnitus starts with ear issues like damaged hair cells but is ultimately
      perceived and amplified as a brain problem, a neurological response
      where the brain creates phantom sounds due to missing signals, involving
      abnormal activity in auditory and emotional centers, making it a
      complex ear-brain issue.

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Side Effects

• Cannabinoid Hyperemesis Syndrome (CHS)
  • Early morning nausea, abdominal pain, and a fear of vomiting

  • Can progress to constant nausea and vomiting, intense pain,
    dehydration and weight loss

  • Cannabis Hyperemesis Syndrome (CHS) @ my.clevelandclinic.org (01/26)

  • This Painful Syndrome is Sending Cannabis Users to the ER @ gwu.edu (01/26)

• THC and Immune System
  • Studies indicate that THC can suppress the immune system by inhibiting
    the function of key immune cells, potentially increasing susceptibility to
    infections. It modulates immune responses, often reducing the body's ability
    to fight off viruses and bacteria.

  • THC suppresses T-cell immunity and reduces the proliferation of T-cells
  • Cannabis use may impair the response to infections like HIV, Hepatitis C,
    and Influenza

  • THC interacts with cannabinoid receptors (CB2) on immune cells, leading
    to a decrease in immune activity

  • The Link Between Cannabis use, Immune System, and Viral Infections @ nih.gov (01/26)
    • Impact of cannabis use on the immune system which may lead to
      increased risk of acquisition and transmission of viral infections
      including HIV, HCV, HTLV-I/II and SARS-CoV2

  • Cannabis and the Immune Response @ sciencedirect.com (01/26)
    • THC generally exhibits immunosuppressive properties beneficial in
      conditions such as autoimmune diseases

• THC and Incontinence
  • Regular, heavy, or long-term consumption of THC is associated with an
    increased risk of developing overactive bladder (OAB) symptoms and urinary
    incontinence in both men and women

  • Cannabinoid receptors are present in the bladder and affect how the
    bladder fills and contracts; excessive activation by THC may lead to dysfunction,
    impacting the bladder's ability to store urine

  • Association Between Recent Cannabis Use and Urinary Incontinence in Women @ nih.gov (01/26)

  • Relationship Between Marijuana Use and Overactive Bladder @ sciencedirect.com (01/26)

• THC and Muscle Weakness
  • Marijuana has been shown to cause muscle weakness and reduce motor neuron
    activity, leading to weaker contractions

  • THC can lead to faster fatigue, decreasing endurance in physical activities
  • Some research indicates that THC can hinder muscle growth by affecting the
    mTOR pathway

  • THC can impair skeletal muscle mitochondrial respiration, which is
    particularly detrimental to muscle energy

  • THC impairs hand-eye coordination, balance, and fine motor skills

  • Cannabinoid signalling inhibits sarcoplasmic Ca2+ release @ nih.gov (01/26)
    • Marijuana was found to cause muscle weakness
    • CB1R activation did not affect muscle force directly, whereas its
      activation decreased the Ca2+‐sensitivity of the contractile apparatus
      and made the muscle fibres more prone to fatigue

• THC and Increased Pain (Hyperalgesia)
  • Daily cannabis use may cause cannabis-induced hyperalgesia (01/26)
    • Although acute THC intake may provide analgesia, chronic,
      high doses cause a desensitization of CB1 and CB2.
    • A withdrawal state is produced by drug cessation.
    • Over 2–4 weeks cannabinoid receptors to return to pre-drug
      baseline

• THC and Peripheral Artery Disease (PAD)
  • Marijuana and Peripheral Vascular Disease @ noh.gov (02/26)
    • Delta-9 THC may accelerate atherosclerosis and PAD
    • Clinical reports have documented cases of cannabis arteritis
    • Cannabis use is associated with acute cardiovascular events
      such as myocardial infarction, arrhythmias, and ischemic stroke

  • Cannabis Arteritis @ sciencedirect.com (02/26)
    • Cannabis arteritis is a serious peripheral vascular disease affecting
      young adults consuming cannabis
    • Cannabis arteritis is often confused with atherosclerosis
    • Complete arterial revascularization was obtained with early aspirin
      treatment
    • Cannabis arteritis should be therefore distinguished from peripheral
      arterial disease caused by atherosclerosis, which is typically not
      reversible

  • Marijuana users were over three times more likely to develop PAD

  • Pain, aches, or cramps in the legs, thighs, or buttocks while
    walking (claudication).

  • Numbness, weakness, or coldness in the lower legs or feet.

  • Slow-healing or non-healing sores on the toes, feet, or legs.

  • Skin changes, such as a pale, blue, or shiny appearance

• THC Withdrawal Symptoms
  • Withdrawal symptoms include physical symptoms such as insomnia,
    headaches, nausea, sweating, tremors, and appetite changes (decreased
    or increased)

  • These symptoms typically start within 24-48 hours, peak around day
    three, and usually last one to two weeks

  • Physical: Headaches, nausea, vomiting, stomach pain, sweating,
    shaking/tremors, night sweats

  • Less Common/High-Potency Symptoms: stomach cramps, restless limbs,
    dry mouth, impaired motor coordination, and slowed perception of time

  • 47% of people who used marijuana regularly experienced withdrawal
    symptoms

  • Cannabis Withdrawal @ nih.gov (01/26)

Top of Page

Results & Side Effects

• Comments from Reddit users
  • "The last two nights I tried high CBD and low THC oil for sleep, and I got
    wide spread tingles that feels like nerve pain."

  • "I get relief from THC but CBD can make me so much worse"

  • "In some cases, CBD can trigger panic attacks"

  • "Some individuals experience shivers and low blood pressure when using CBD,
    especially in higher doses"

  • CBD side effects can include chills, fever, drowsiness, and lower back
    or side pain.

  • Fever is a common side effect of Epidiolex (CBD) treatment.

  • "I haven't noticed CBD specifically making it worse for me but for sure CBG.
    I took it because it is suppose to help with pain and i swear it amplified it 10 fold"

  • "Test results from today:
    CBD + THC = increased pain
    THC = no pain"

  • "I discovered THC works like magic on my MS pain and fatigue. I still don't
    know exactly why, but I also can't tolerate CBD on its own.

  • "If THC is providing both pain relief and side effects, it makes sense that
    increasing CBD would reduce both the pain relief and side effects, because CBD
    is acting in the opposite direction of THC."

  • "I have the same symptoms from too much THC, in addition to a fever."

  • "Only low-dose THC helps my chronic pain. The normal 15% plus gives me a
    weird rebound pain that makes my skin hurt (plus paranoia)."

  • "THC does tend to reduce pain more reliably, but CBD still has value,
    just not as a classic analgesic. CBD can lower inflammation, calm central
    sensitization and reduce anxiety around pain, which indirectly improves
    function for some people."

• Mike's comments
  • Took CBD+CBG with Tylenol: nerves burned all over the body for 4 hours
    (took WAY TOO MUCH CBD)

  • WyldCBD Gummies (20mg CBD + 10mg CBG) was weak; 2 gummies were nice

  • beeZbee CBD+CBG (12.5mg + 12.5mg) tincture took a long time to be felt

  • 5mg CBD + 5mg Delta-9 THC
    • Reduced pain and produced a body high in a 150-pound man
    • Eyesight and hearing improved
    • By far the best mix that has been tested
    • CBD+THC in a 1:1 ratio is often called the "golden ratio" (entourage effect)
    • The 1:1 ratio aims for a functional calm, providing mild euphoria with
      therapeutic relief

  • 10mg CBD + 5mg Delta-9 THC four times a day is a good first guess

  • Took 5mg CBD + 7.5mg Delta-9 THC four times a day
    (less sleepy, but a little bit high)

  • Now taking 2.5mg CBD + 7.5mg THC four time a day
    (even less sleepy, but still a little bit high)

  • Tried the Buddha Beans Delta-9 Tincture; 20 drops is a nice dose;
    25 drops for "bubble toes"

  • Tried Nano THC powder from deltachocolateshop.com; this is NOT
    work for Mike and was very expensive for what you got

Top of Page

Cost Analysis

• Delta-9 THC
  • We will use "bubble toes" as the test; that dose seems to be
    7.5mg Delta-9 THC (in a gummy)

  • beeZbee Delta-9 THC Gummies (12/25)
    • $1.72/dose (half a gummy); $6.90/day; $207/month
      • 15mg each gummy; dose is 7.5mg (half a gummy)
      • $25 for 5 gummies; paid $75 for 20 gummies ($69.01 with tax)
      • 15% discount at CBD Kratom
      • Purchased locally at CBD Kratom @ Stonebrook, Frisco (12/25)

  • Cloud City Buddha Beans Delta-9 THC Tincture, 300mg in 30ml; $20.00 (12/25)
    • Dosage
      • Dose seems to be 25 drops (24 doses/bottle)
      • 12.5mg of nano Delta-9 THC = 7.5mg of standard Delta-9 THC

    • Special Offers
      • Delta-9 THC Tincture, 300mg in 30ml; $20.00 (normal price)
        • $0.83/dose (25 drops); $3.33/day; $100.00/mo
      • Grab 2 bottles for $35 sale
        • $0.73/dose (25 drops); $2.91/day; $87.50/mo
      • Free shipping over $100; otherwise shipping is $10

    • I ordered this and it arrived in 6 days

    • Lab Results (12/25)

  • Delta-9 Nano Powder @ deltachocolateshop.com (12/25)
    • Lab Report
      • 213.8mg Delta-9 THC/gm powder = 21.38% Delta-9 THC
      • This suggests I need 35mg powder to equal 7.5mg Delta-9 THC

    • 25% discount for veterans; 20% discount STOCKUP20

    • Known amounts
      • 1/2 tsp = 1000mg
      • 1/8 tsp = 250mg

    • THIS DOES NOT WORK FOR MIKE

Top of Page

CBD Gummies

• Information
  • CBD Gummies for Beginners @ restartcbd.com (12/25)
    • The effects of CBD gummies typically take longer to set in compared to other
      forms of CBD, such as tinctures or vaping
    • The effects of CBD gummies tend to last longer than other methods of consumption,
      often providing relief for 4 to 6 hours

• Comparisons
  • Best CBD Gummies @ forbes.com (12/25)

  • Best CBD Gummies @ medicalnewstoday.com (12/25)
    • Best overall gummies: Cornbread Hemp Organic Berry CBD Gummies

    • Most affordable CBD gumming: Medterra Max Relief CBD Gummies

    • Highest dose of CBD: CBDfx Mixed Berry CBD Gummies

    • Best vegan CBD gummy: Soul CBD Gummies

    • Best gummies for stress: Sunday Scaries Extra Strength CBD Gummies

    • Best fast-acting CBD: FOCL Daily Calm Full Spectrum Gummies

• Specific Gummies
  • Smokiez @ cloudcitysupplyinc.com (12/25)
    • Smokiez CBD Gummies, 25mg, $20 for 10 (different doses) (12/25)
    • Smokiez CBD:CBG 2.5:1, $25-$35 (12/25)
    • Lab Results (12/25)

  • WYLD Pear Gummies (20mg CBD + 10 mg CBG; THC Free; 40 gummies) (12/25)
    • $1.50 per gummie
    • Purchased at Cheech & Chong's Aphothicaria (FM 423 & Lebanon)
    • Can be purchased at CBD Plus Gold in Prosper (12/25)

Top of Page

CBD+THC Gummies

• CBD+THC Gummies, microdose
  • Afternoon Delight CBD+THC+CBG Gummies @ slumbercbn.com ($60 for 30 gummies) (12/25)
    • 30mg CBD + 5mg THC (Delta-9) + 10mg CBG per gummy
    • Lab Report (12/25)
    • Full spectrum
    • Peach Lemonade
    • Website has multiple discounts, including 35FORLIFE (autoship)
    • American Shaman has 5-gummy sample pack ($13) and 30 gummies for $67

  • Cruise Chews, 33mg full spectrum, 30 chews, $59.99 (12/25)
    • CBD+THC gummies
    • 31.35mg CBD + 3.3mg THC (Delta-9)
    • Lab Reports (12/25)
    • Military discount of 20% at Lebanon location

  • The High Confectionary Uplift Sour Peach Gummies (12/25)
    • 1mg CBD + 1mg Delta-9 THC
    • Expensive, but can be used to determine correct dosage of THC
    • $50.00 for 50 gummies
    • Purchased at CBD Kratom @ Stonebrook, Frisco (12/25)
    • CBD Kratom @ Stonebrook, Frisco ($50.00) (12/25)

• CBD+THC Gummies, larger dose
  • beeZbee CBD + Delta-9 THC 1:1 (12/25)
    • 10mg CBD + 10mg THC per gummy
    • $25 for 5 gummies; $75 for 20 gummies
    • 15% discount at CBD Kratom
    • Test Results for CBD+THC Gummies (12/25)

  • Cypress Hemp (12/25)
    • CBD:THC 1:1 Ratio Gummies
      • 5mg CBD + 5mg THC: 30 gummies, strawberry, $35.00 (30 doses, $1.17/dose)
      • 10mg CBD + 10MG THC: 25 gummies, $40.00 (50 doses, $0.80/dose)
      • 20mg CBD + 20mg THC: 15 gummies, $45.00 (60 doses, $0.75/dose)
    • CBD:THC 2:5 Ratio Gummies
      • 20mg CBD + 8 mg THC, sour apple, 30 gummies, $32.00 (30 doses, $1.07/dose) (12/25)

  • Cycling Frog Blue Razz Gummies CBD+THC 10mg each, 40 gummies, $40.00 (12/25)

• Delta-9 THC Gummies
  • beeZbee Delta-9 THC Gummies (12/25)
    • 15mg each gummy
    • $25 for 5 gummies; $75 for 20 gummies
    • 15% discount at CBD Kratom
    • Test Results for Delta-9 gummies (12/25)
    • Purchased at CBD Kratom @ Stonebrook, Frisco (12/25)

• Delta-8 THC Gummies
  • beeZbee Delta-8 THC Gummmies (12/25)
    • 20mg each gummy
    • $65 for 20 gummies
    • Test Results for Delta-8 gummies (12/25)

Top of Page

Tinctures

• Definitions
  • Tincture
    • Normally an oil-based solution
    • Can contain CBD, CBG, THC, or a combination
    • Can have very high concentrations
    • Normally is flavored, but can still taste like pine trees
    • Usually is quite expensive

  • Mixer
    • Is a water-based solution
    • Normally contains a nano-solution of Delta-9 THC
    • I have not found a water-based solution of CBD
    • Has much lower concentrations (for making mocktails)
    • Can be much less expensive for the same amount of Delta-9 THC
    • Can be flavored or unflavored

  • Powder
    • Delta-9 Islolate Powder @ americanextractions.com (12/25)
    • Is a powder (crystals) to be added to cool drinks or food
    • Normally is Delta-9 THC
    • Has a lower concentration
    • Can be much less expensive than tinctures
    • Doesn't have any flavor
    • Absorption occurs in just 15 minutes with 4.5 times the
      absorption of cannabis oil
    • Nano doesn't work for everyone! We all have receptors
      and we accept it differently

• CBD Tinctures
  • beeZbee CBD+CBG Tincture, Reg Strength (375mg + 375mg) $80.00 (12/25)
    • Dose: 12.5mg+12.5mg; $2.67
    • Lab Report for High Strength Version (12/25)
    • Purchased at CBD Kratom Frisco (near DNT) for $68.00; $73.61 total
    • 15% veteran discount

  • Colorado Cures 500mg CBD BROAD Spectrum Tincture, Tropical ($9.99) (12/25)
    • 500mg in 30ml; 16.7mg/dose; $0.33/dose (dose=1ml; very good price)
    • Apply half of the serving under the tongue twice daily (morning and evening),
      and let it sit for 1-2 minutes before swallowing
    • This has a Tropical flavor
    • I ordered this and it arrived in 6 days

  • Colorado Cures 500mg CBD FULL Spectrum Tincture, Tropical ($34.99) (12/25)
    • 500mg in 30ml; 16.7mg/dose; $1.16/dose
    • Does NOT contain CBG
    • You can see the difference between a FULL spectrum and a BROAD spectrum product

• CBD + Delta-8 THC Tinctures
  • beeZbee CBD & Delta-8 2:1 Tincture, Low Strength ($38.00) (12/25)
    • 5mg CBD & 2.5mg Delta-8

  • beeZbee CBD + Delta-8 Tincture (2:1), High Strength @ shopcbdkratom.com (01/25)
    • 1200mg CBD + 600mg Delta-8-THC; 1800mg Total Cannabinoids (2:1 ratio)
    • 1200mg CBD + 240mg Delta-88-THC; 1440mg Total Cannabinoids (5:1 ratio)

• Delta-8 THC Tinctures
  • Hometown Hero Delta-8 THC Tincture, Berry (12/25)
    • 20mg Delta-8 THC per ml
    • COA (12/25)

Top of Page

Mixers & Powders

• Definitions
  • Tincture
    • Normally an oil-based solution
    • Can contain CBD, CBG, THC, or a combination
    • Can have very high concentrations
    • Normally is flavored, but can still taste like pine trees
    • Usually is quite expensive

  • Mixer
    • Is a water-based solution
    • Normally contains a nano-solution of Delta-9 THC
    • I have not found a water-based solution of CBD
    • Has much lower concentrations (for making mocktails)
    • Can be much less expensive for the same amount of Delta-9 THC
    • Can be flavored or unflavored

  • Powder
    • Delta-9 Islolate Powder @ americanextractions.com (12/25)
    • Is a powder (crystals) to be added to cool drinks or food
    • Normally is Delta-9 THC
    • Has a lower concentration
    • Can be much less expensive than tinctures
    • Doesn't have any flavor
    • Absorption occurs in just 15 minutes with 4.5 times the
      absorption of cannabis oil
    • Nano doesn't work for everyone! We all have receptors
      and we accept it differently

• CBD Nano Drops
  • DRAM Cloud Drops, CBD ($79.00) (01/26)
    • High potency Water Soluble CBD Drops
    • One ounce contains 1500mg CBD; 3mg/drop; 600 drops/bottle
    • This product is intended for mixing, not direct sublingual dosing
    • It is not flavored, but it does have a bit of bitterness on the end
    • Ingredients: Non GMO Glycerin, Colorado Hemp Extract, Lemon Salt, Water

• CBD + CBG Mixer
  • cbdMD Delta-9 THC Drink Mixer ($34.99) (12/25)
    • 3 mg Delta-9 THC + 3 mg CBG per serving
    • Available in Black Cherry or Unflavored
    • Water soluble

• Delta-9 THC Mixers
  • 502Hemp Cannabis Mocktail Creator 100mg ($29.99) (12/25)
    • 100mg Delta-9 THC/50ml Bottle
    • Water soluble, FLAVORLESS
    • Use as much or little as you like

  • Cloud City Buddha Beans Delta-9 THC Tincture, 300mg in 30ml; $20.00 (12/25)
    • There are 60 5mg doses in a bottle ($0.33/dose; very good price)
    • Water-soluble formula (nano-emulsification); enhanced bioavailability
    • FLAVORLESS
    • Lab Results (12/25)
    • I ordered this and it arrived in 6 days

  • Medicineman Hemp Co Delta-9 Nano Mixers ($15.99) (12/25)
    • 200mg Delta-9 THC in squeeze packets; 8 packets for $15.99; $2/packet
    • Each squeeze contains 25mg of Delta-9 THC (like flavorings for water)
    • Ingredients: Water, Citric Acid, Sodium Citrate, Sucralose, AceK,
      Natural and Artificial Flavors, Delta 9 THC (Nanoemulsified), Salt,
      Sodium Benzoate, Caffeine (only in Turbo Diesel)
    • Mix into any non-alcoholic beverage
    • You could pour a squeeze packet into a dropper bottle and subdivide;
      40 5mg servings for $2.00 = $0.05/dose

  • Primo Vibes Delta-9 Tincture ($30.00) (12/25)
    • 88mg total (3mg/ml); 5mg total per dropper
    • Blue Raspberry (Euphoria) and Pineapple (Chill)
    • Cheech & Chong's sell this locally

  • ZAR Cosmic Mixer Delta-9, 75mg/30ml; $39.99 (01/25)
    • 75mg/30ml = 2.5mg/ml (can be divided)
    • FLAVORLESS
    • Sold locally at ZAR Wellness

• Delta-9 THC Powder
  • CBDivine Delta-9 THC Dissolvable (12/25)
    • Ten 10mg packets for $27.50
    • Odorless and flavorless
    • Absorption occurrs in just 15 minutes with 4.5 times the absorption of cannabis oil

  • Hometown Hero Dash, Unflavored THC Powder @ hometownhero.com ($39/10ct) (01/26)
    • Each serving of DASH delivers 10 mg Delta-9 THC
    • Ingredients: Allulose, Potassium Citrate, Citric Acid, Magnesium Glycinate,
      Nano-Emulsified Water-Soluble Hemp Derived Delta-9 THC, Vitamin B-12

  • Hometown Hero Dash Delta-9 THC Drink Mix Powder @ procannabis.com (12/25)
    • 1 packet for $4.99
    • Each packet contains 10mg Delta-9 THC
    • Unflavored, dissolvable powder; sugar-free formulation
    • Avoid heating above 315 deg F, as that's where THC begins to break down
    • Lab Report (12/25)

  • Delta-9 Nano Powder @ deltachocolateshop.com (12/25)
    • 2000mg Nano Delta-9 THC for $75.00 (includes shipping)
      • Dose is 25mg (small spoon) which equals 5.345mg D-9 THC
      • $0.175 per mg; $1.32/7.5mg dose; $5.26/day
      • Will last for years in a cabinet away from direct sunlight
      • There are no fillers in our Nano powder

    • Lab Report
      • Powder contains 213.8mg D-9 THC / 1000mg of powder
      • Powder is approximately 1/5 D-9 THC

    • The website lists these measurements
      • 1/2 teaspoon = 1000mg powder = 213.8mg D-9 THC
      • 1/4 teaspoon = 500mg
      • 1/8 teaspoon = 250mg powder = 53.45mg D-9 THC

    • They include a tiny 25mg measuring spoon
      • Appears to be 1/40 tsp
      • This means that the tiny measuring spoon holds
        50mg powder IF you use the measurements listed
        above
      • That equates to 10.64mg D-9 THC (the chemical)
      • BUT they state that the tiny measuring spoon holds
        25mg which equates to 5.345mg D-9 THC
      • Their statements are not consistent

Top of Page

Topicals

• Overview
  • CBD (cannabidiol) possesses moderate-to-high skin permeability
    for topical use and can cross the blood-brain barrier, though it has
    low water solubility and poor oral bioavailability

  • The permeability of CBD is highly dependent on the vehicle used. For
    example, a gel with 25% diethylene glycol monoethyl ether (DEGEE) and
    25% ethanol showed the highest skin penetration in some studies

  • Evaluation of Skin Permeability of CBD @ nih.gov (01/26)

  • Human Cannabinoid Pharmacokinetics @ nih.gov (12/25)
    • Permeabilities of CBD and CBN were found to be 10-fold higher
      than for Delta-8 THC
    • Transdermal delivery also bypasses first-pass metabolism of
      cannabinoids

• Creams
  • beeZbee CBD Pain Cream, Unscented, Single Serving ($4.80) (01/26)
    • Found locally at CBD Kratom
    • 30mg CBD/serving
    • Simply tear off the corner of the packet and apply the cream
      to your desired area

  • Colorado Cures 250mg CBD Hot Cream, 1 oz (30ml), $19.99 (12/25)

  • Crystal Creek CBD Relief Gel ($49.99) (01/26)
    • Found locally at Frisco Wellness & Botanicals
    • Container holds 1000mg CBD in 3.4 fl oz (100ml)
    • Serving is 10mg/ml, but could be subdivided

  • Hemp Menstrual Cramp Roll-on ($29.99) (01/26)
    • Found locally at Frisco Wellness & Botanicals
    • Container holds 2000mg CBD in 1.7 fl oz (50ml)

  • CBD Creams @ walmart.com (01/26)
    • Charlotte's Web CBD Isolate 1000mg Cream, 1.4 fl oz @ walmart.com ($14.98) (01/26)
      • 714mg/oz; $0.015/mg
      • Found at
        • Stonebrook & FM 423(?)
        • Richland Blvd (Prosper; NE corner of Preston & 380; S of Richland Blvd)
        • Ohio (Plano; S of 121, E of Preston, W of Ohio Dr)
        • Custer (McKinney; SW corner of 380 & Custer)
        • 16066 St Hiway 121 (Frisco; NW corner of 121 & Custer)
      • Charlotte's Web Debuts New CBD Topical Collection
        at Walmart on June 26, 2024 (01/26)
        • Consumers will find Charlotte's Web CBD topical products in 827
          Walmart stores across five states including California, Illinois,
          Florida, Texas, and Pennsylvania
        • The new line of competitively priced CBD topicals is formulated
          with CBD isolate

    • Medterra CBD Isolate 1200mg Roll-on, 3.0 fl oz @ walmart.com ($18.98)
      • 400mg/oz; $0.0125/mg
      • Aisle G8 of Eldorado store

    • Medterra CBD Isolate 2000mg Cream, 3.4 fl oz @ walmart.com ($18.98) (01/26)
      • 3.4 fl oz = 100 ml (2000mg CBD / 100ml cream)
      • 588mg/oz; $0.0095/mg
      • Should be at Stonebrook store
      • Aisle G8 of Eldorado store

    • Medterra CBD Broad Spectrum 2000mg CBD Cream, 3.4 fl oz ($19.98) (01/26)
      • 3.4 fl oz = 100 ml (2000mg CBD / 100ml cream)
      • 588mg/oz; $0.0099/mg
      • Not found in store; shipping only

  • Brands that do NOT contain any CBD
    • 5Kind
    • Blue-Emu
    • Hempvana

• Patches
  • CBD Patches for Sale @ CBDliving.com ($15.00) (01/26)
    • Patch is infused with 100mg Broad Spectrum Nano CBD
    • Provides up to 96 hours of extended relief

  • Select CBD Patch and Social CBD Patch (instacart)

Top of Page

Recipes

• Homemade CBD Gummies @ lovecheflaura.com (12/25)

Top of Page

Online Stores

• beeZbee
  • beeZbee CBD+CBG Tincture, Reg Strength (375mg + 375mg) $80.00 (12/25)
    • Dose: 12.5mg+12.5mg; $2.67
    • Purchased at CBD Kratom Frisco (near DNT) for $68.00; $73.61 total

• Cheech & Chong's
  • Lab Reports for Cheech & Chong's (12/25)

  • Cruise Chews, 33mg full spectrum, 30 chews, $59.99 (12/25)
    • CBD+THC gummies
    • 31.35mg CBD + 3.3mg THC

• Cloud City Supply (01/26)
  • Free shipping: $100+

  • Buddha Beans Delta-9 THC Tincture, 300mg in 30ml; $20.00 (12/25)

  • Cloud City Roll-On 1500mg CBD (01/26)

  • Smokiez @ cloudcitysupplyinc.com (12/25)

• Colorado Cures (free shipping)
  • CBD Plus USA is a sister site (12/25)

  • Colorado Cures 25mg Full Spectrum Gummies, 10 ct, $19.99 (12/25)
    • CBD isolate, Full Spectrum hemp derived distillate
    • 22.638mg CBD + 2.256mg THC

  • Colorado Cures 500mg CBD BROAD Spectrum Tincture, Tropical ($9.99) (12/25)
    • 500mg in 30ml; 16.7mg/dose; $0.33/dose

  • Colorado Cures 500mg CBD FULL Spectrum Tincture, Tropical ($34.99) (12/25)
    • 500mg in 30ml; 16.7mg/dose; $1.16/dose
    • 17.8 mg/ml CBD + 0.92 mg/ml THC

  • Colorado Cures 250mg CBD Hot Cream, 1 oz (30ml), $19.99 (12/25)

• WyldCBD
  • Pear Gummies CBD+CBG (12/25)

Top of Page

Stores

• Artisan Vapor & CBD Frisco
  • 12398 FM 423 #1200, Frisco, TX 75033
  • NE corner of FM 423 and Eldorado (Walmart shopping center, north side)
  • Phone: 469-516-0899
  • Hours: Mon-Sat: 10:00am - 9:00pm; Sun: 11am - 7:00pm
  • CBD Lab Reports (12/25)
  • Delta-8 THC Tincture, 1500mg/30ml; $40.00 (one in stock)
  • Most things are much too strong

• Cannabis Cowboys (01/26)
  • 6726 Main St, Suite 420, Frisco, TX 75033
  • In the Rainhead District
  • Hours: Sun-Thu: 10am-11pm; Fri-Sat: 10am-12am
  • Phone: 469-626-8410
  • Email: info@420cowboy.com
  • Shop Here (01/26)
  • Most things are much too strong

• CBD American Shaman of Frisco
  • 8745 Gary Burns Dr, Ste 136, Frisco, TX 75034
    • North of the Walmart on Preston & Hickory St (has light)
    • Behind Krispy Kreme Donuts (on Preston)
    • South of Ernesto's Fine Mexican Rood (same building)
    • Not too far from ZAR Wellness (on the east side of Preston, south of Hickory St)
  • Hours: Mon-Thu: 10:00am-7:00pm; Sat: 10:00am-8:00pm; Sun: 11:00am-5:00pm
  • Afternoon Delight gummies: 30mg CBD + 5mg THC + 10mg CBG
    ($12.95 for 5; $67 for 30 gummies)

• CBD Kratom Frisco @ Stonebrook (12/25)
  • NW corner of Stonebrook & DNT
  • Mon-Sun: 8:00am - 10:00 pm
  • Phone: 972-704-3359
  • CBD oils, tinctures, and gummies for relaxation and pain relief
  • beeZbee CBD THC-Free Gummies, 30 mg each, 12 gummies; $34.00 (12/25)
  • beeZbee CBD+CBG Tincture, Reg Strength, 30 ml; 375mg+375mg; $80.00 retail (12/25)
    • Military discount 15%: $68.00; total $73.61; $2.45/dropper
    • 1/2 to 1 full dropper one to two times per day, depending on desired effect
  • Sell Delta-8 THC Tincture (out of stock)

• CBD Plus USA (12/25)
  • Stores appear to be permanently closed
  • Products
    • Colorado Cures brand
    • beeZbee gummies
    • Smokiez brand gummies; 25 mg; 20 for $10
    • Colorado Cures 500mg Broad Spectrum Tincture, 30ml; $9.99 (12/25)

• CBD Plus Gold (12/25)
  • Prosper
    • 2111 E University Dr, Suite 50, Prosper
    • NW corner of Coit & 380; next to Discount Tire
    • Hours: Mon-Sat: 11am - 8pm; Sun 12pm - 5pm
  • McKinney
  • Products
    • WyldCBD 300mg Broad Spectrum CBD CBG Pear Gummies ($59.99) (12/25)

• Cheech & Chong's Apothicaria (12/25)
  • Frisco
    • 5480 FM 423 Suite 500, Frisco, TX
    • SE corner of Lebanon & FM 423 (south of Tom Thumb)
    • Phone: 469-200-5636
    • Hours: M-S: 10am - 10pm; Sun: 11am - 8pm
  • The Colony
    • 3751 Main St, Suite 150B, The Colony, TX
    • SW corner of FM 423/Main St and Memorial Dr (just north of 121)
    • Phone: 972-704-3200
  • Products
    • WYLD Pear Gummies (20 mg CBD + 10 mg CBG; THC Free;
      broad spectrum; 40 gummies; good price)

• Dallas Hemp Co (01/26)
  • We deliver within a 15 mile radius of our store

• Frisco Wellness & Botanicals (01/25)
  • 7151 Preston Rd, Suite #111a, Frisco, TX
    • Preston Stonebrook Center
    • SW corner of Stonebrook & Preston
    • (ZAR Wellness is on the NE corner, a little further north)
  • Hours: Mon-Sat: 11am-10pm; Sun: 12pm-6pm
  • Phone: 469-888-4045
  • This store is part of a chain
  • Order Products (01/26)
  • Hemp Menstrual Cramp Roll-on ($29.99) (01/26)

• House of Vapes
  • 5855 Preston Rd, Ste 100B, Frisco, TX 75034
  • NW corner of Lebanon Rd & Preston Rd
  • North of Providence Church, next to Indian restaurant
  • Phone: 945-241-1760
  • Hours: Mon-Sat: 9:00am-12:00am; Sun: 9:00am-10:00pm

• Smoke Art Tobacco
  • Rail District location (12/25)
    • 6801 Main St, Frisco, TX 75034
    • Phone: 214-407-8334
  • North Frisco Location
    • 2440 Eldorado Pkwy, Frisco, TX 75033
    • NW corner of Eldorado & Teel (close to Sprouts)
    • Phone: 214-407-7830
    • Hours: Sun-Sat: 10am - 11pm
    • Very good selection of products; helpful store manager
  • West Frisco location
    • 615 Main St, Frisco, TX 75034
    • Next to Bank of America
    • Phone: 469-200-5070
    • Hours: Mon-Sun: 8am - 3am

• ZAR Wellness (12/25)
  • Frisco location
    • 7932 Preston Rd Ste 200, Frisco, TX 75034
    • NE corner of Preston and Stonebrook/Rolator (north of NTB Tire)
    • Hours: Sun-Mon: closed; Tue-Sat: 11am - 7pm
    • 972-352-1532
  • Veterans receive 22% off on all quality hemp cannabis products
  • They provide delivery and product samples
  • "We pride ourselves in providing the best quality products at below market prices"
  • ZAR Cosmic Mixer Delta-9, 75mg/30ml; $39.99 (01/25)
    • 10% off the Cosmic Mixer to celebrate the New Year

Top of Page

Labware

• Beaker
  • 150ml Beaker @ northtexashomebrew.com ($4.99) (01/26)
    • 17811 Davenport Rd, Suite 11, Dallas, TX 75252
    • South of Preston & Frankford (south of George Bush)
    • 423 S => Parker E => Preston S => Frankford E => Davenport S
    • Phone: 469-206-6227
    • Hours: Mon-Fri: 12-6; Sat: 9-5

• Eye Dropper Bottle
  • Vivalpex, 12 Amber 2-oz (60ml) Glass Bottles with Glass Eye Droppers @ walmart.com
    ($9.99 + shipping; arrives tomorrow; fulfilled by Walmart) (01/26)

• Graduated Cylinder
  • 50ml
    • 50ml Glass Graduated Cylinder Eisco Labs @ walmart.com
      ($13.59; free shipping; arrives in 1 week) (01/26)

    • 50ml Glass Graduated Cylinder Karter Scientific @ walmart.com
      ($7.98 + shipping; arrives in 3 days; fulfilled by Walmart) (01/26)

    • 50ml Polypropylene Graduated Cylinder Karter Scientific @ walmart.com
      ($7.49; free shipping; in 1 week) (01/26)

  • 100ml
    • 100ml Graduated Cylinder Brewing America @ walmart.com
      ($8.95 + shipping; tomorrow) (01/26)

    • 100mg Plastic Graduated Cylinder @ walmart.com
      ($2.04 + $4.99 shipping; in 2 weeks) (01/26)

  • 10ml, 50ml, and 100ml
    • 10ml, 50ml, & 100ml Glass Graduated Cylinders BioRx Labs @ walmart.com
      (19.99; free shipping; in 2 weeks) (01/26)

• Oral Syringe, 10ml
  • Lifetime Pharmacy
    • SW corner of FM 423 & Lebanon Rd

• Stirring Rod
  • Chopstick?

Top of Page

Legislation

• FDA
  • FDA currently considers Delta-8 THC to be a Schedule I drug, just like cannabis
  • On December 18, 2025, Proseident Trump signed an executive order to
    expedite the process of moving marijuana from a Schedule I to Schedule III
    controlled substance.

• Farm Bill of 2018
  • Hemp Farming Act of 2018 @ wikipedia.org (12/25)
    • Law to remove hemp (defined as cannabis with less than 0.3% THC) from
      Schedule I controlled substances and making it an ordinary agricultural
      commodity
    • Became law on December 20, 2018 (signed by Donald Trump)
    • Mitch McConnell introduced the bill

• FY2026 Agriculture Appropriations Act
  • What to Expect in the Wake of the Federal Hemp Product Ban (12/25)

  • Change to Federal Definition of Hemp @ congress.gov (12/25)

  • Brief Description of the Bill
    • Signed in November 2025, and takes effect on November 12, 2026
    • Closed the "hemp loophole" created by the 2018 Farm Bill, which only
      regulated delta-9 THC concentrations
    • The legal threshold for hemp is now defined by a "total THC" concentration
      of not more than 0.3% on a dry weight basis, which includes delta-9 THC,
      THCA, and other cannabinoids with similar effects
    • There is a strict cap of 0.4 milligrams of total THC per container
      which makes most gummies illegal
    • Any cannabinoids that are synthesized (such as delta-8 THC) are now
      excluded from the definition of legal hemp and classified as Schedule I
      controlled substances

• Current State Restrictions
  • Unintended Consequences of a Federal Hemp Ban (12/25)
    • There are over forty (40) states with finished hemp product regulations
      including more than a dozen states with robust regulatory frameworks,
      including AL, CO, CT, FL, LA, NY, TN, MN, GA, KY, IA and VA.
    • Today, forty (40) states plus Washington D.C. and three (3) U.S. territories
      have some form of state-legal regulated cannabis despite its federal illegality.
    • The hemp industry supports ~320,000 American jobs and generates
      $28.4 billion in regulated market activity.
    • In Texas alone, a ban would shut down approximately 6,350 businesses,
      force job losses for 40,000 citizens, and destroy $7.5 billion in economic activity.
    • The hardest hit will likely to be American farmers, for whom hemp has been a
      lifeline since 2018.

  • Cannabis & Hemp Product Laws by State (2025) @ procannabis.com (01/26)

• Pending Federal Bills
  • Executing Action Revives Federal Marijuana Rescheduling Efforts (01/25)

  • American Hemp Protection Act of 2025 @ congress.gov (12/25)
    • Aims to simply repeal Section 781 of the appropriations bill, thereby
      preventing the impending ban from taking effect

  • HEMP Act of 2025 @ congress.gov (12/25)
    • Aims to increase the legal delta-9 THC limit from 0.3% to 1%

  • Cannabinoid Safety and Regulation Act @ congress.gov (12/25)
    • Cannabinoid Safety and Regulation Act (12/25)
    • Edible (oral) products may only contain 5mg of THC per serving,
      and 50mg THC per package

  • H.R.7024 Hemp Planting Predictability Act @ congress.gov (01/26)
    • Introduced on Jan 13, 2026
    • Bipartisan legislation to protect the 2026 hemp planting season
    • To provide a two-year extension of the current hemp framework,
      which was to expire on November 12, 2026
    • Congressman Comer's speech on the floor (01/26)

  • H.R.7212 - Hemp Enforcement, Modernization and Protection (HEMP) Act (01/26)
    • HEMP Act @ morgangriffith.house.gov (01/26)
    • Introduced on January 23, 2026
    • Intended to create the pathway for federal regulation of cannabidiol (CBD)
      products
    • This bill only regulates hemp-derived products and not cannabis
    • FDA must initiate a rulemaking process to set milligram limits of CBD
      products
    • If the FDA fails to release a final rule within three years of the measure's
      enactment, federal law will automatically establish CBD intoxicating
      limits of 5 milligrams per serving and 30 milligrams per package
    • The Hemp Planting Predictability Act is designed to protect American
      hemp farmers from what is virtually a ban on hemp products by providing
      a two-year extension to the November 2026 ban (now in effect)

  • Comments
    • There is uncertainty about how broadly the federal law will be
      enforced, potentially leaving the regulatory landscape in a complex
      state where enforcement varies between federal and state authorities.

• Texas Legislation
  • Governor Greg Abbott's Executive Order on September 10, 2025 (01/26)
    • Governor Greg signed Executive Order GA-56 which orders state
      agencies to establish a 21 and over age limit on hemp product sales,
      and to review and revise testing and labeling standards for hemp
      products

  • Texas Moves Ahead with Regulating Hemp Industry
    @ texastribune.org (12/25)

  • DSHS Proposed Hemp Rule (01/26)
    • Texas Set to Ban Smokeable Cannabis As Soon As Jan 25, 2026 @
      houstonpublicmedia.org (01/26)
      • Age restriction (over 21) and mandatory ID verification
      • Fee increases of roughly 10,000% for manufacturers and retailers
      • Annual fees for hemp manufacturers would jump from $250 to
        $25,000 per facility
      • Retailers would be required to pay $20,000 per location each year,
        up from the current $150 registration fee
      • Online retailers based outside of Texas who sell products into
        Texas must also obtain a DSHS Retail Hemp Registration
      • The proposed rules would still allow for edible hemp products,
        like gummies and drinks containing Delta-9, Delta-8 and potent
        cannabinoids such as THCP
      • The proposed rules would include THCA amounts in the calculation
        of Delta-9 THC levels, a change that would effectively outlaw most
        smokable hemp products
      • "The proposed rules wipe out about 80% of what all shops sell"
      • The drafted rules would not affect the state’s medical marijuana
        program
      • Oneline retailers requirements
        • Have a DSHS Retail Hemp Registration
        • Age verification with VERY strict verfication (government IDs)
        • Registration fee increases to $20,000

    • Texas Hemp THC Licensing Fee Increase @ texastribune.org (01/26)
      • The Texas Alcoholic Beverage Commission and the Texas Department
        of State Health Services have both proposed new rules aimed at regulating
        the consumable hemp market
      • 8,000 licensed hemp retailers who fall under the Department of
        State Health Services include smoke shops, gas stations, and online
        retailers that do not sell liquor and presumably do not hold a liquor
        license
      • Lt. Gov. Dan Patrick has been an ardent supporter of a ban on
        consumable hemp products

    • Consumable Hemp Program @ dshs.texas.gov (01/26)

• What Can We Do?
  • Contact Representatives

  • Support industry groups
    • U.S. Hemp Roundtable (12/25)
      • Industry Updates @ hempsupporter.com (12/25)

      • Help Stop the Hemp Ban (01/26)

  • Monitor legislation

  • Raise awareness

Top of Page

Bonnie's Links
created by Bonnie Lee Hill,
bonniehill@verizon.net
last modified on February 8, 2026

URL: http://www.bonniehill.net/pages/cbd.html